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KMID : 0369819920220010023
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Jorunal of Korean Pharmaceutical Sciences
1992 Volume.22 No. 1 p.23 ~ p.31
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Controlled Drug Delivery through O - Diethylaminoethyl Chitosan Membrane
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김진홍/Kim JH
이영무/Lee YM
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Abstract
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A novel O-diethylaminoethyl chitosan (DEAE-chitosan) was synthesized via Schiff's reaction between chitosan and benzaldehyde. C2 amino group was protected via Schiffs base reaction with benzaldehyde to form N-benzylidene chitosan. After reaction with diethylaminoethyl chloride, Schiffs base was removed by reacting O-diethylaminothyl-N-benzylidene chitosan and hydrochloric acid. Tensile strength of DEAE-chitosan was improved due to the incorporation of bulky side group in C6 position of chitosan. DEAE-chitosan showed a pH-dependent swelling characteristics. Release rate of riboflavin was dependent on the water content of DEAE-chitosan that is a function of crosslinking degrees.
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